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New Study Shows mRNA Boosters May Hinder Immune System Response To COVID — Here’s The 411

This would explain why the jabbed seem to take longer to recover from a milder version of the virus.

A new report published in the medical journal Science Immunology just days before Christmas innocuously titled, “Class switch towards non-inflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination” shows some disturbing data regarding the effect of multiple mRNA shots on the immune system.

A thread by one of the authors admits that there was an “unexpected rise” in a specific type of antibody — Immunoglobin G4 (IgG4) — after the third mRNA shot.

The immune response after the booster appears to shift so that the body produces more IgG4 antibodies and fewer of the other antibodies that are more effective at attacking the SARS-CoV-2 virus.

The change could mean that people who have had their three (or more) mRNA shots are more susceptible to COVID infection as well as prolonged — and perhaps more serious — illness once they do contract the virus.

These results are specific to the mRNA shots.


Here is one of the authors of the study explaining the findings.

In one tweet, Schober did try to downplay the attention that the pre-print study is getting among “aNtI-vAxXeRs” by insisting that the mRNA shots have (essentially) been “safe and effective.”

In a later tweet, however, he admits that since the mRNA technology is being explored for use in the treatment of autoimmune diseases and cancer, the increase of IgG4 “clearly requires further investigation.”

Meanwhile, some of the big pro-vax voices out there are clearly troubled by the study.

Over the course of the last two days, I’ve read articles and Substack posts about the significance in the immune system’s shift to producing IgG4 post-booster written by doctors, scientists, journalists, and the average Joe just trying to wrap their heads around what the heck is going on.

Independent journalist Alex Berenson explained it this way, “IgG4 has been shown to become more common in people chronically exposed to allergens. Beekeepers famously develop higher levels of IgG4 antibodies to bee venom over time, for example.”

Here is Substack author Igor Chudov explaining the significance of this study in very simple terms.

Our immune systems are complicated. We do need to fight dangerous replicating pathogens, such as viruses or bacteria. At the same time, we also face harmless inert substances, such as tree pollen, that sometimes cause inflammatory reactions called allergies.
To deal with these harmless substances, our immune system has a particular class of antibodies, called IgG4, that do the opposite of what we are used to hearing: they bind to allergens and tell our immune cells to ignore them rather than cause inflammation.

He then explains that it appears that the mRNA shots are working like allgery shots.

I had many pollen allergies. Every spring was unpleasant. I decided to go to an allergist and take allergy shots, which amounted to repeatedly injecting allergens into me. As a result of these repeat antigen shots, my immune system developed non-inflammatory IgG4 antibodies, which mark pollen as a harmless substance to the rest of my immune system and prevent allergic inflammation and nasty symptoms.
There is something important, though: pollen does not replicate.
It is a good idea not to have inflammation in response to pollen. It is a bad idea, however, to train our immune system to ignore replicating pathogens such as Sars-Cov-2.

Sometimes memes can get the idea across in a way that all the technical language can’t.

Berenson concluded his article on Substack with this:

…[I]f the mRNAs are truly generating broad “immune tolerance” to a virus that continues to mutate its spike and make all our anti-spike protein antibodies less potent (as Omicron has), the long-term consequences are potentially frightening.
At the least, this paper offers more evidence that mRNA booster campaigns need to be immediately restricted. And scientists need to examine whether people with high post-vaccination levels of IgG4 antibodies are becoming sicker than people with lower levels. If they are, we need an immediate effort to look for tools to reverse or slow switching to IgG4 at the cellular level.
Physicians will also have to be on the lookout for a spike in IgG4 related disease, which generally manifests as autoimmune disorders and is usually fairly responsive to steroids.
Source: Unreported Truths (Dec. 27, 2022)

It’s important to note that this doesn’t mean that boosted people have no ability to mount an immunological response if they are infected by COVID-19, it just means that it may be a longer, lingering illness and put a strain on their immune system. In addition, it potentially puts them at risk for organ damage from the virus because their immune system is taking a longer time to fight off the virus.

What does that mean long term for a virus that will soon become an endemic virus like the flu? Who knows. Only time will tell.

Dear Christian: Your Fear Is Full of Crap

by Doug Giles

Beginning in March 2020, many Christians went into lockdown-freak-out mode. Uncut, irrational, unbiblical, and not to mention, unconstitutional, fear gripped many churches and church leaders. Forced to choose between obeying the Word of God or the edict of man, most Western Churches buckled. We even saw it here in First Amendment-protected America.

The Apostle Peter buckled to fear on the night of Christ’s crucifixion. But he learned his lesson and lived the rest of his life bold as a lion. How can the church ‘go and do likewise’?

Read the book and find out!

Get your copy of Dear Christian: Your Fear Is Full of Crap now. Better yet, grab an extra copy for any petrified pastor who dutifully put obedience to the unconstitutional edicts of Mayor McCheese ahead of obedience to the explicit commandments of the LORD God Almighty.

K. Walker

ClashDaily's Associate Editor since August 2016. Self-described political junkie, anti-Third Wave Feminist, and a nightmare to the 'intersectional' crowd. Mrs. Walker has taken a stand against 'white privilege' education in public schools. She's also an amateur Playwright, former Drama teacher, and staunch defender of the Oxford comma. Follow her humble musings on Twitter: @TheMrsKnowItAll and on Gettr @KarenWalker